- Source: 1-Aminoindane
1-Aminoindane (1-AI), also known as 1-aminoindan, 1-indanylamine, or 1-indanamine, is an aminoindane. It is a positional isomer of 2-aminoindane. A variety of notable derivatives of 1- and 2-aminoindane are known. The (R)-enantiomer of 1-aminoindan, (R)-1-aminoindan, is pharmacologically active and is an active metabolite of the antiparkinsonian agent rasagiline.
Pharmacology
Through its (R)-enantiomer (R)-1-aminoindane, 1-aminoindane has pharmacological activity. It specifically shows neuroprotective and catecholamine-modulating actions.
Chemistry
1-Aminoindane is an aminoindane. It is a racemic mixture of (R)- and (S)-enantiomers. The (R)-enantiomer is (R)-1-aminoindan, which has pharmacological activity and is an active metabolite of the antiparkinsonian agent rasagiline.
A number of notable 1-aminoindane derivatives exist. These include the following:
1-Aminoindan-1,5-dicarboxylic acid (AIDA) – selective mGlu1 receptor antagonist
1-Amino-5-phosphonoindan-1-carboxylic acid (APICA) – selective mGlu2 and mGlu3 receptor antagonist
AGN-1135 (racemic rasagiline; N-propargyl-1-aminoindane) – irreversible MAO-B inhibitor
Indatraline (Lu 19-005) – serotonin–norepinephrine–dopamine reuptake inhibitor
Ladostigil (TV-3326) – irreversible MAO-B inhibitor and reversible acetylcholinesterase and butyrylcholinesterase inhibitor
Ozanimod (Zeposia) – sphingosine-1-phosphate receptor agonist
Rasagiline (Azilect; N-propargyl-(R)-1-aminoindane) – selective irreversible MAO-B inhibitor and neuroprotective agent
SU-11739 (AGN-1133; J-508; N-methyl-N-propargyl-1-aminoindane) – non-selective monoamine oxidase inhibitor and catecholamine releasing agent
Zicronapine (Lu 31-130) – experimental atypical antipsychotic (D1, D2, and 5-HT2A receptor antagonist)
Jimscaline, 2CB-Ind, and AMMI are derivatives of 1-aminomethylindane, an indane- and amine-containing compound closely related to 1-aminoindane.
1-Aminoindane is a positional isomer of 2-aminoindane. A variety of notable 2-aminoindane derivatives also exist.
