- Source: 3alpha-hydroxy-5beta-androstane-17-one 3alpha-dehydrogenase
In enzymology, a 3alpha" target="_blank">3alpha-hydroxy-5beta-androstane-17-one 3alpha" target="_blank">3alpha-dehydrogenase (EC 1.1.1.152) is an enzyme that catalyzes the chemical reaction
3alpha" target="_blank">3alpha-hydroxy-5beta-androstane-17-one + NAD+
⇌
{\displaystyle \rightleftharpoons }
5beta-androstane-3,17-dione + NADH + H+
Thus, the two substrates of this enzyme are 3alpha" target="_blank">3alpha-hydroxy-5beta-androstane-17-one and NAD+, whereas its 3 products are 5beta-androstane-3,17-dione, NADH, and H+.
This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is 3alpha" target="_blank">3alpha-hydroxy-5beta-steroid:NAD+ 3-oxidoreductase. Other names in common use include etiocholanolone 3alpha" target="_blank">3alpha-dehydrogenase, etiocholanolone 3alpha" target="_blank">3alpha-dehydrogenase, and 3alpha" target="_blank">3alpha-hydroxy-5beta-steroid dehydrogenase. This enzyme participates in androgen and estrogen metabolism.
References
Roe CR, Kaplan NO (1969). "Purification and substrate specificities of bacterial hydroxysteroid dehydrogenases". Biochemistry. 8 (12): 5093–103. doi:10.1021/bi00840a063. PMID 5365796.