- Source: Acoltremon
Acoltremon also known as WS-12 is an investigational new drug which is being evaluated for the treatment of dry eye syndrome.
Acoltremon that acts as a potent and selective activator (opener) of the TRPM8 calcium channel, which is responsible for the sensation of coldness produced by menthol. It is slightly less potent as a TRPM8 activator compared to icilin, but is much more selective for TRPM8 over related calcium channels. It produces analgesic and antiinflammatory effects in animal models with similar efficacy to menthol and a reduced side effect profile.