- Source: BCL2-related protein A1
Bcl-2-related protein A1 is a protein in humans which is encoded by the BCL2A1 gene.
Function
This gene encodes a member of the bcl2 protein family. The proteins of this family form hetero- or homodimers and act as anti- and pro-apoptotic regulators that are involved in a wide variety of cellular activities such as embryonic development, homeostasis, and tumorigenesis. The protein encoded by this gene can reduce the release of pro-apoptotic cytochrome c from mitochondria and block caspase activation. This gene is a direct transcription target of NF-kappa B in response to inflammatory mediators and is up-regulated by different extracellular signals, such as granulocyte-macrophage colony-stimulating factor (GM-CSF), CD40, phorbol ester, and inflammatory cytokine TNF and IL-1, which suggests a cytoprotective function that is essential for lymphocyte activation as well as cell survival.
In melanocytic cells BCL2A1 gene expression may be regulated by MITF.
Interactions
BCL2-related protein A1 has been shown to interact with:
Bcl-2-associated X protein, and
Bcl-2-associated death promoter.
References
External links
Human BCL2A1 genome location and BCL2A1 gene details page in the UCSC Genome Browser.
Further reading
Kata Kunci Pencarian:
- BCL2-related protein A1
- List of A1 genes, proteins or receptors
- Bcl-2
- DNA damage-inducible transcript 3
- Myc
- Bcl-2 homologous antagonist killer
- Cell division
- Apolipoprotein B
- APOBEC1
- Stress granule
