• Source: Bile duct hamartoma

Bile duct hamartoma or biliary hamartoma, are benign lesions of the intrahepatic bile duct. They are classically associated with polycystic liver disease, as may be seen in the context of polycystic kidney disease, and represent a malformation of the liver plate.




Signs and symptoms


Most patients are asymptomatic. When patients do present with symptoms the most common symptom is abdominal pain. Other symptoms include fever, weight loss, and jaundice.




Causes


Biliary duct hamartomas are defects resulting from the failure of embryonic bile duct involution that affect the small interlobular bile ducts. Patients with polycystic kidney disease and polycystic liver are far more likely to have them.




Diagnosis












Laboratory findings include high transaminase levels, raised gamma-glutamyl transferase or alkaline phosphatase levels, increased C-reactive protein, hypoalbuminemia, and hematologic abnormalities like thrombocytopenia, leukopenia, leukocytosis, and anemia.
At CT scans, bile duct hamartomas appear as small, well-defined hypo- or isoattenuating masses with little or no enhancement after contrast administration. At MRI, they appear hypointense on T1-weighted images, iso- or slightly hyperintense on T2-weighted images, and hypointense after administration of gadolinium based contrast-agent.




Eponym


The eponymous terms (von Meyenburg complex, Meyenburg complex) are named for Hanns von Meyenburg.




Additional images























See also


Cholestasis
Ground glass hepatocyte
Mallory body




References






Further reading


Zheng, Rong Qin; Kudo, Masatoshi; Onda, Hirokazu; Inoue, Tatsuo; Maekawa, Kiyoshi; Minami, Yasunori; Chung, Hobyung; Kitano, Masayuki; Kawasaki, Toshihiko (2005-12-19). "Imaging findings of biliary hamartomas (von Meyenburg complexes)". Journal of Medical Ultrasonics. 32 (4): 205–212. doi:10.1007/s10396-005-0051-1. ISSN 1346-4523. PMID 27277490. S2CID 25856248.




External links


StatPearls
British Liver Trust

Kata Kunci Pencarian:

• Bile duct hamartoma
• Polycystic liver disease
• Gastrointestinal disease
• Congenital hepatic fibrosis
• List of syndromes
• Index of oncology articles
• Causes of cancer
• List of MeSH codes (C04)