E-64 is an epoxide which can irreversibly inhibit a wide range of cysteine peptidases.
The compound was first isolated and identified from Aspergillus japonicus in 1978. It has since been shown to inhibit many cysteine peptidases such as papain, cathepsin B, cathepsin L, calpain and staphopain.
The low toxic effects of the inhibitor, in addition to its effective mechanism of action, makes E-64 a potential template for drugs to treat diseases where high levels of a cysteine proteases are the primary cause.
E64 may refer to:
BMW E64, a car model in the BMW 6 Series
European route E64, a series of roads in Italy, part of the United Nations International E-road network
E-64, an epoxide which can irreversibly inhibit a wide range of cysteine peptidases
King's Indian Defence, Encyclopaedia of Chess Openings code
Tsugaru Expressway, route E64 in Japan
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