- Source: List of mayors of Cape Girardeau, Missouri
- List of mayors of Cape Girardeau, Missouri
- Cape Girardeau, Missouri
- George C. Thilenius
- Millersville, Missouri
- List of mayors of Poplar Bluff, Missouri
- List of mayors of Charleston, Missouri
- Kennett, Missouri
- List of mayors of Portageville, Missouri
- Albert Spradling Jr.
- List of mayors of Perryville, Missouri
The city of Cape Girardeau, Missouri, is the most populous city in Missouri's 8th congressional district and southeastern Missouri which is sometimes known as the Missouri Bootheel.
List of Mayors
Cape Girardeau mayors since 1843, when the city was incorporated.