• Source: MAPK1

Mitogen-activated protein kinase 1 (MAPK 1), also known as ERK2, is an enzyme that in humans is encoded by the MAPK1 gene.




Function


The protein encoded by this gene is a member of the MAP kinase family. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. The activation of this kinase requires its phosphorylation by upstream kinases. Upon activation, this kinase translocates to the nucleus of the stimulated cells, where it phosphorylates nuclear targets. Two alternatively spliced transcript variants encoding the same protein, but differing in the UTRs, have been reported for this gene. MAPK1 contains multiple amino acid sites that are phosphorylated and ubiquitinated.




Interactions


MAPK1 has been shown to interact with:




Clinical significance


Mutations in MAPK1 are implicated in many types of cancer.




See also


Extracellular signal-regulated kinases




References






Further reading






External links


MAP Kinase Resource Archived 2021-04-15 at the Wayback Machine.

Kata Kunci Pencarian:

• Pengatur sinyal kinase ekstraseluler
• Daftar gen penyandi protein pada manusia/2
• MAPK1
• Extracellular signal-regulated kinases
• P42
• 22q11.2 distal deletion syndrome
• Mitogen-activated protein kinase
• TIRAP
• Angelman syndrome
• Transcytosis
• AMP-activated protein kinase
• Chromosome 22