Northup is a surname. Notable people with the surname include:
Amos Northup (1889–1937), American automotive designer
Anne Northup (born 1948), American politician
Diana Northup, American biologist
James M. Northup (1820–1899), New York politician
Jeremiah Northup (1816–1879), Canadian merchant, shipowner, and politician
Jeremiah Northup (Nova Scotia politician) (died 1809), Nova Scotia politician
Harry Northup (born 1940), American actor and poet
Nancy Northup (born 1960), American political activist
Nate Northup (born 1981), American soccer player
Oliver Northup (1925–2013), American murder victim
Solomon Northup (1808–1863), American farmer, violinist and author
Stephen Northup (circa 1630–after 1687), early settler of the Colony of Rhode Island and Providence Plantations
Willard C. Northup (1882–1942), American architect
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