• Source: SCN3B

Sodium channel subunit beta-3 is a protein that in humans is encoded by the SCN3B gene. Two alternatively spliced variants, encoding the same protein, have been identified.




Function


Voltage-gated sodium channels are transmembrane glycoprotein complexes composed of a large alpha subunit and one or more regulatory beta subunits. They are responsible for the generation and propagation of action potentials in neurons and muscle. This gene encodes one member of the sodium channel beta subunit gene family, and influences the inactivation kinetics of the sodium channel.




Clinical significance


Mutations in the gene are associated with abnormal cardiac electrophysiology.




See also


Sodium channel




References






Further reading






External links


GeneReviews/NIH/NCBI/UW entry on Brugada syndrome
SCNB3+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
This article incorporates text from the United States National Library of Medicine, which is in the public domain.

Kata Kunci Pencarian:

• SCN3B
• Brugada syndrome
• Sodium channel
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