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Progressive transformation of germinal centres GudangMovies21 Rebahinxxi LK21

Progressive transformation of germinal centres (PTGCs) is a reactive lymph node process of undetermined cause.




Signs and symptoms


PTGC is usually characterized by localized lymphadenopathy and is otherwise typically asymptomatic.




Diagnosis



PTGC is diagnosed by surgical excision of the affected lymph node(s), and examination by a pathologist. The differential diagnosis includes non-neoplastic causes of lymphadenopathy (e.g. cat-scratch fever, Kikuchi disease) and malignancy, i.e. cancer.




= Microscopic appearance

=
PTGCs is characterized by:

follicular hyperplasia (many follicles),
focally large germinal centres, with poorly demarcated germinal centre (GC)/mantle zone interfaces (as GCs infiltrated by mantle zone lymphocytes), and
an expanded mantle zone.




Treatment


PTGC is treated by excisional biopsy and follow-up. It may occasionally recur and a small proportion of patients have been reported to subsequently develop nodular lymphocyte predominant Hodgkin lymphoma.




See also


Lymphadenopathy
Nodular lymphocyte predominant Hodgkin lymphoma




References






External links

Kata Kunci Pencarian:

• Progressive transformation of germinal centres
• Mantle cell lymphoma
• Martinique
• Transhumanism
• Epstein–Barr virus–associated lymphoproliferative diseases
• Environmental history
• List of vegetarians
• Polio
• List of nominees for the Nobel Prize in Physiology or Medicine
• MiR-155

99-Progressive Transformation of Germinal Centers | PDF

Progressive transformation of germinal centres - Wikiwand

Progressive transformation of germinal centers - Libre Pathology

Progressive transformation of germinal centers - Libre Pathology

Progressive transformation of germinal centers - Libre Pathology

Progressive transformation of germinal centers - Libre Pathology

Progressive transformation of germinal centers - Libre Pathology

Progressive transformation of germinal centers - Libre Pathology

Progressive Transformation of Germinal Centers | Basicmedical Key

Progressive Transformation of Germinal Centers | Basicmedical Key

Progressive transformation of germinal centers - Libre Pathology

Progressive transformation of germinal centers - Libre Pathology