• Source: (3,5-dihydroxyphenyl)acetyl-CoA 1,2-dioxygenase

(3,5-dihydroxyphenyl)acetyl-CoA 1,2-dioxygenase (EC 1.13.11.80, DpgC) is an enzyme catalyses the following chemical reaction

(3,5-dihydroxyphenyl)acetyl-CoA + O2 ⇌ 2-(3,5-dihydroxyphenyl)-2-oxoacetate + CoA.
This enzyme is involved in the biosynthesis of the nonproteinogenic amino acid (S)-3,5-dihydroxyphenylglycine (Dpg) responsible of the production of vancomycin and teicoplanin antibiotics. It catalyzes the unusual conversion 3,5-dihydroxyphenylacetyl-CoA (DPA-CoA) to 3,5-dihydroxyphenylglyoxylate.




References

Kata Kunci Pencarian:

• (3,5-dihydroxyphenyl)acetyl-CoA 1,2-dioxygenase
• Index of molecular biology articles
• List of EC numbers (EC 1)