- Source: (acyl-carrier-protein) phosphodiesterase
The enzyme [acyl-carrier-protein] phosphodiesterase (EC 3.1.4.14) catalyzes the reaction
holo-[acyl-carrier-protein] + H2O
⇌
{\displaystyle \rightleftharpoons }
4′-phosphopantetheine + apo-[acyl-carrier-protein]
This enzyme belongs to the family of hydrolases, specifically those acting on phosphoric diester bonds. The systematic name is holo-[acyl-carrier-protein] 4′-pantetheine-phosphohydrolase. Other names in common use include ACP hydrolyase, ACP phosphodiesterase, AcpH, and [acyl-carrier-protein] 4′-pantetheine-phosphohydrolase. This enzyme participates in pantothenate and CoA biosynthesis.
Structural studies
As of late 2007, two structures have been solved for this class of enzymes, with PDB accession codes 1T5B and 1TIK.
References
Sobhy C (1979). "Regulation of fatty acid synthetase activity. The 4′-phosphopantetheine hydrolase of rat liver". J. Biol. Chem. 254 (17): 8561–6. doi:10.1016/S0021-9258(19)86929-6. PMID 224058.
Vagelos PR, Larrabes AR (1967). "Acyl carrier protein. IX. Acyl carrier protein hydrolase". J. Biol. Chem. 242 (8): 1776–81. doi:10.1016/S0021-9258(18)96069-2. PMID 4290442.
Thomas J, Cronan JE (2005). "The enigmatic acyl carrier protein phosphodiesterase of Escherichia coli: genetic and enzymological characterization". J. Biol. Chem. 280 (41): 34675–83. doi:10.1074/jbc.M505736200. PMID 16107329.
Kata Kunci Pencarian:
- (acyl-carrier-protein) phosphodiesterase
- Peripheral membrane protein
- Phosphodiester bond
- Phosphatidic acid
- List of EC numbers (EC 3)
- List of enzymes
- Acetyl-CoA carboxylase
- SpoT
- Chromosome 11
- Chromosome 17
