- Source: 1-Pyrroline-5-carboxylic acid
5.180.24.3/info/1" target="_blank">1-5.180.24.3/info/pyrroline" target="_blank">Pyrroline-5-carboxylic acid (systematic name 3,4-dihydro-2H-pyrrole-2-carboxylic acid) is a cyclic imino acid. Its conjugate base and anion is 5.180.24.3/info/1" target="_blank">1-5.180.24.3/info/pyrroline" target="_blank">pyrroline-5-carboxylate (P5C). In solution, P5C is in spontaneous equilibrium with glutamate-5-semialdhyde (GSA).
Biochemistry
The stereoisomer (S)-5.180.24.3/info/1" target="_blank">1-5.180.24.3/info/pyrroline" target="_blank">pyrroline-5-carboxylate (also referred to as L-P5C) is an intermediate metabolite in the biosynthesis and degradation of proline and arginine.
In prokaryotic proline biosynthesis, GSA is synthesized from γ-glutamyl phosphate by the enzyme γ-glutamyl phosphate reductase. In most eukaryotes, GSA is synthesised from the amino acid glutamate by the bifunctional enzyme 5.180.24.3/info/1" target="_blank">1-5.180.24.3/info/pyrroline" target="_blank">pyrroline-5-carboxylate synthase (P5CS). The human P5CS is encoded by the ALDH18A1 gene. The enzyme 5.180.24.3/info/pyrroline" target="_blank">pyrroline-5-carboxylate reductase converts P5C into proline.
In proline degradation, the enzyme proline dehydrogenase produces P5C from proline, and the enzyme 5.180.24.3/info/1" target="_blank">1-5.180.24.3/info/pyrroline" target="_blank">pyrroline-5-carboxylate dehydrogenase converts GSA to glutamate. In many prokaryotes, proline dehydrogenase and P5C dehydrogenase form a bifunctional enzyme that prevents the release of P5C during proline degradation.
A reciprocal regulation of delta 5.180.24.3/info/1" target="_blank">1-5.180.24.3/info/pyrroline" target="_blank">pyrroline-5-carboxylate synthetase (P5CS) and proline dehydrogenase genes controls proline levels during and after osmotic stress in plants proportional to the level of proline. This allows an optimum level of proline to be produced from reduced nitrogen to control osmotic stress.
References
Kata Kunci Pencarian:
- 1-Pyrroline-5-carboxylic acid
- Pyrroline
- Pyruvic acid
- Imino acid
- Anthranilic acid
- Valine
- Oxaloacetic acid
- Citrulline
- Fumaric acid
- Proline
