- Source: 1921 Whitman Fighting Missionaries football team
The 1921 Whitman Fighting Missionaries football team represented Whitman College as a member of the Northwest Conference during the 1921 college football season. Led by sixth-year head coach Vincent Borleske, the Fighting Missionaries compiled an overall record of 4–2 with a mark of 3–0 in conference play, winning the Northwest Conference. Ben Comrada, a graduate of Ballard High School in Seattle, played at tackle and was the team captain. Whitman played home games at Ankeny Field in Walla Walla, Washington.