• Source: 2,4-Diaminobutyric acid

2,4-Diaminobutyric acid, also known as DABA, is GABA-T non-competitive inhibitor and a GABA reuptake inhibitor.




Mechanism of action


DABA's main action is being an inhibitor of GABA transaminase, an enzyme that converts GABA back to glutamate. When the enzyme is inhibited, this conversion cannot happen, therefore, GABA levels are elevated.
It has also been observed that 2,4-diaminobutyric acid is a GABA reuptake inhibitor. This action further elevates levels of GABA.




Toxicity


In addition to being a neurotoxin, DABA can also cause liver damage.
Its potential as an anticonvulsant is unclear, it has been shown to have anticonvulsant properties against picrotoxin, but over the long term, it could paradoxically cause convulsions.




References

Kata Kunci Pencarian:

• Kamus rumus kimia
• 2,4-Diaminobutyric acid
• Ectoine
• Pyoverdine
• Daba
• Leucobacter komagatae
• Rathayibacter toxicus
• C4H10N2O2
• Diaminobutyrate—pyruvate transaminase
• Leucobacter
• Agromyces