- Source: 2,5-dioxopiperazine hydrolase
In enzymology, a 2,5-dioxopiperazine hydrolase (EC 3.5.2.13) is an enzyme that catalyzes the chemical reaction
2,5-dioxopiperazine + H2O
⇌
{\displaystyle \rightleftharpoons }
glycylglycine
Thus, the two substrates of this enzyme are 2,5-dioxopiperazine and H2O, whereas its product is glycylglycine.
This enzyme belongs to the family of hydrolases, those acting on carbon-nitrogen bonds other than peptide bonds, specifically in cyclic amides. The systematic name of this enzyme class is 2,5-dioxopiperazine amidohydrolase. Other names in common use include cyclo(Gly-Gly) hydrolase, and cyclo(glycylglycine) hydrolase.
References
Suzuki Y, Uchida K (1985). "Multiple forms of alpha-glycosidase from pig duodenum". Agric. Biol. Chem. 49 (6): 1573–1581. doi:10.1271/bbb1961.49.1573.