- Source: 2006 Hampton Pirates football team
The 2006 Hampton Pirates football team represented Hampton University as a member of the Mid-Eastern Athletic Conference (MEAC) in the 2006 NCAA Division I FCS football season. They were led by fifteenth-year head coach Joe Taylor and played their home games at Armstrong Stadium. They finished the season with a 10–2 overall record, won the MEAC championship with a 7–1 record in conference play and earned a berth to the first round of the NCAA Division I playoffs, where they were defeated by New Hampshire.
Hampton won the black college football national championship as awarded by three selectors, with North Carolina Central chosen by five other selectors.