- Source: 3,4,5-Trimethoxybenzaldehyde
3,4,5-Trimethoxybenzaldehyde is an organic compound and a biochemical. Within this class of compounds, the chemical is categorized as a trisubstituted aromatic aldehyde.
Uses
3,4,5-Trimethoxybenzaldehyde can be used as an intermediate in the synthesis of some pharmaceutical drugs including trimethoprim, cintriamide, roletamide, trimethoquinol (aka tretoquinol), and trimazosin as well as some psychedelic phenethylamines.
Preparation
= Industrial scale
=For industrial applications the chemical is synthesized from p-cresol using aromatic substitution with bromine followed by nucleophilic substitution with sodium methoxide. Oxidation of the methyl group to an aldehyde can occur via various synthetic methods.
= Laboratory scale
=At the laboratory scale the chemical is conveniently synthesized from vanillin or from Eudesmic acid's Acyl chloride via Rosenmund reduction.
