• Source: 3-demethylubiquinone-9 3-O-methyltransferase

In enzymology, a 3/info/3" target="_blank">3-3/info/demethylubiquinone" target="_blank">demethylubiquinone-3/info/9" target="_blank">9 3/info/3" target="_blank">3-O-methyltransferase (EC 2.1.1.64) is an enzyme that catalyzes the chemical reaction

S-adenosyl-L-methionine + 3/info/3" target="_blank">3-3/info/demethylubiquinone" target="_blank">demethylubiquinone-3/info/9" target="_blank">9



⇌


{\displaystyle \rightleftharpoons }

S-adenosyl-L-homocysteine + ubiquinone-3/info/9" target="_blank">9
Thus, the two substrates of this enzyme are S-adenosyl methionine and 3/info/3" target="_blank">3-3/info/demethylubiquinone" target="_blank">demethylubiquinone-3/info/9" target="_blank">9, whereas its two products are S-adenosylhomocysteine and ubiquinone-3/info/9" target="_blank">9.
This enzyme participates in ubiquinone biosynthesis.




Nomenclature


This enzyme belongs to the family of transferases, specifically those transferring one-carbon group methyltransferases. The systematic name of this enzyme class is S-adenosyl-L-methionine:2-nonaprenyl-3/info/3" target="_blank">3-methyl-5-hydroxy-6-methoxy-1, 4-benzoquinone 3/info/3" target="_blank">3-O-methyltransferase. Other names in common use include 5-3/info/demethylubiquinone" target="_blank">demethylubiquinone-3/info/9" target="_blank">9 methyltransferase, OMHMB-methyltransferase, 2-Octaprenyl-3/info/3" target="_blank">3-methyl-5-hydroxy-6-methoxy-1,4-benzoquinone, methyltransferase, S-adenosyl-L-methionine:2-octaprenyl-3/info/3" target="_blank">3-methyl-5-hydroxy-6-methoxy-, and 1,4-benzoquinone-O-methyltransferase.




References



Houser RM, Olson RE (June 1977). "5-3/info/demethylubiquinone" target="_blank">demethylubiquinone-3/info/9" target="_blank">9-methyltransferase from rat liver mitochondria. Characterization, localization, and solubilization". The Journal of Biological Chemistry. 252 (12): 4017–21. PMID 863914.
Leppik RA, Stroobant P, Shineberg B, Young IG, Gibson F (March 1976). "Membrane-associated reactions in ubiquinone biosynthesis. 2-Octaprenyl-3/info/3" target="_blank">3-methyl-5-hydroxy-6-methoxy-1,4-benzoquinone methyltransferase". Biochimica et Biophysica Acta (BBA) - General Subjects. 428 (1): 146–56. doi:10.1016/0304-4165(76)90116-1. PMID 769831.

Kata Kunci Pencarian:

• 3-demethylubiquinone-9 3-O-methyltransferase
• O-methyltransferase
• Coq3 O-methyltransferase
• COQ3
• Lactoylglutathione lyase