• Source: 3-hydroxyacyl-CoA dehydrogenase

In enzymology, a 3-hydroxyacyl-CoA dehydrogenase (EC 1.1.1.35) is an enzyme that catalyzes the chemical reaction

(S)-3-hydroxyacyl-CoA + NAD+



⇌


{\displaystyle \rightleftharpoons }

3-oxoacyl-CoA + NADH + H+
Thus, the two substrates of this enzyme are (S)-3-hydroxyacyl-CoA and NAD+, whereas its 3 products are 3-oxoacyl-CoA, NADH, and H+.
This enzyme belongs to the family of oxidoreductases, to be specific those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor.




Isozymes


In humans, the following genes encode proteins with 3-hydroxyacyl-CoA dehydrogenase activity:

HADH – Hydroxyacyl-Coenzyme A dehydrogenase
HSD17B10 – 3-Hydroxyacyl-CoA dehydrogenase type-2
EHHADH – Peroxisomal bifunctional enzyme
HSD17B4 – Peroxisomal multifunctional enzyme type 2




Function


3-Hydroxyacyl CoA dehydrogenase is classified as an oxidoreductase. It is involved in fatty acid metabolic processes. Specifically it catalyzes the third step of beta oxidation; the oxidation of L-3-hydroxyacyl CoA by NAD+. The reaction converts the hydroxyl group into a keto group.

The end product is 3-ketoacyl CoA.




Metabolic pathways


This enzyme participates in 8 metabolic pathways:




Nomenclature


The systematic name of this enzyme class is (S)-3-hydroxyacyl-CoA:NAD+ oxidoreductase. Other names in common use include:




Structural studies


As of 20 January 2010, 22 structures have been solved for this class of enzymes, with PDB accession codes 1F0Y, 1F12, 1F14, 1F17, 1F67, 1GZ6, 1IKT, 1IL0, 1LSJ, 1LSO, 1M75, 1M76, 1S9C, 1WDK, 1WDL, 1WDM, 1ZBQ, 1ZCJ, 2D3T, 2HDH, 3HAD, and 3HDH.




References

Kata Kunci Pencarian:

• Long-chain 3-hydroxyacyl-coenzyme A dehydrogenase deficiency
• 3-hydroxyacyl-CoA dehydrogenase
• 3-hydroxyacyl-coenzyme A dehydrogenase deficiency
• HADHA
• Hydroxyacyl-Coenzyme A dehydrogenase
• Beta oxidation
• Enoyl CoA isomerase
• Short-chain acyl-CoA dehydrogenase
• Acetyl-CoA
• Acyl-CoA