- Source: 4,5:9,10-diseco-3-hydroxy-5,9,17-trioxoandrosta-1(10),2-diene-4-oate hydrolase
3/info/4,5:9,10" target="_blank">4,5:9,10-3/info/diseco" target="_blank">diseco-3-hydroxy-5,9,17-trioxoandrosta-1(10),2-diene-4-oate hydrolase (EC 3.7.1.17, tesD (gene), hsaD (gene)) is an enzyme with systematic name 3/info/4,5:9,10" target="_blank">4,5:9,10-3/info/diseco" target="_blank">diseco-3-hydroxy-5,9,17-trioxoandrosta-1(10),2-diene-4-oate hydrolase ( (2Z,4Z)-2-hydroxyhexa-2,4-dienoate-forming). This enzyme catalyses the following chemical reaction
(1E,2Z)-3-hydroxy-5,9,17-trioxo-3/info/4,5:9,10" target="_blank">4,5:9,10-disecoandrosta-1(10),2-dien-4-oate + H2O
⇌
{\displaystyle \rightleftharpoons }
3-[(3aS,4S,7aS)-7a-methyl-1,5-dioxo-octahydro-1H-inden-4-yl]propanoate + (2Z,4Z)-2-hydroxyhexa-2,4-dienoate
The enzyme is involved in the bacterial degradation of the steroid ring structure.
References
External links
3/info/4,5:9,10" target="_blank">4,5:9,10-3/info/diseco" target="_blank">diseco-3-hydroxy-5,9,17-trioxoandrosta-1(10),2-diene-4-oate+hydrolase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)