- Source: 4-alpha-glucanotransferase
In enzymology, a 4-alpha-glucanotransferase (EC 2.4.1.25) is an enzyme that catalyzes a chemical reaction that transfers a segment of a 1,4-alpha-D-glucan to a new position in an acceptor carbohydrate, which may be glucose or a 1,4-alpha-D-glucan.
This enzyme belongs to the family of glycosyltransferases, specifically the hexosyltransferases. The systematic name of this enzyme class is 1,4-alpha-D-glucan:1,4-alpha-D-glucan 4-alpha-D-glycosyltransferase. Other names in common use include disproportionating enzyme, dextrin glycosyltransferase, D-enzyme, debranching enzyme maltodextrin glycosyltransferase, amylomaltase, and dextrin transglycosylase. This enzyme participates in starch and sucrose metabolism in plants. Studies of the enzyme from potato led to the discovery of cycloamylose.
Structural studies
As of late 2007, 14 structures have been solved for this class of enzymes, with PDB accession codes 1CWY, 1ESW, 1FP8, 1FP9, 1K1W, 1K1X, 1K1Y, 1LWH, 1LWJ, 1TZ7, 1X1N, 2OWC, 2OWW, and 2OWX.
References
Hehre EJ (1951). "Enzymic Synthesis of Polysaccharides: A Biological type of Polymerization". Advances in Enzymology and Related Areas of Molecular Biology. Advances in Enzymology - and Related Areas of Molecular Biology. Vol. 11. pp. 297–337. doi:10.1002/9780470122563.ch6. ISBN 978-0-470-12256-3. PMID 24540594. {{cite book}}: |journal= ignored (help)
Lukomskaya, I. S. (1959). "Синтез oligosaccharides с alpha-1,6-bonds приготовлениями фермента от печени и мускула" [Synthesis of oligosaccharides with alpha-1,6-bonds by enzyme preparations from liver and muscle]. Doklady Akademii Nauk SSSR (in Russian). 129: 1172–1175.
Pazur JH, Okada S (1968). "The isolation and mode of action of a bacterial glucanosyltransferase". J. Biol. Chem. 243 (18): 4732–8. doi:10.1016/S0021-9258(18)93179-0. PMID 4972097.
Walker GJ, Whelan WJ (1959). "Synthesis of amylose by potato D-enzyme". Nature. 183 (4653): 46. Bibcode:1959Natur.183...46W. doi:10.1038/183046a0. PMID 13622683. S2CID 4289861.
Whelan WH (1971). "Enzymic explorations of the structures of starch and glycogen". Biochem. J. 122 (5): 609–622. doi:10.1042/bj1220609. PMC 1176828. PMID 5001952.
Kata Kunci Pencarian:
- 4-alpha-glucanotransferase
- Cyclomaltodextrin glucanotransferase
- Glycogen debranching enzyme
- Active site
- Glycoside hydrolase family 77
- Glycogen storage disease type III
- Α-Amylase
- Glycoside hydrolase family 57
- Cycloisomaltooligosaccharide glucanotransferase
- Glycogen branching enzyme
