- Source: 4-oxalmesaconate hydratase
The enzyme 4-oxalmesaconate hydratase (EC 4.2.1.83) catalyzes the chemical reaction
2-hydroxy-4-oxobutane-1,2,4-tricarboxylate
⇌
{\displaystyle \rightleftharpoons }
(1E,3E)-4-hydroxybuta-1,3-diene-1,2,4-tricarboxylate + H2O
This enzyme belongs to the family of lyases, specifically the hydro-lyases, which cleave carbon-oxygen bonds. The systematic name of this enzyme class is (1E,3E)-4-hydroxybuta-1,3-diene-1,2,4-tricarboxylate 1,2-hydro-lyase (2-hydroxy-4-oxobutane-1,2,4-tricarboxylate-forming). Other names in common use include 4-carboxy-2-oxohexenedioate hydratase, 4-carboxy-2-oxobutane-1,2,4-tricarboxylate 2,3-hydro-lyase, oxalmesaconate hydratase, γ-oxalmesaconate hydratase, 4-carboxy-2-oxohexenedioate hydratase, and 2-hydroxy-4-oxobutane-1,2,4-tricarboxylate 2,3-hydro-lyase. This enzyme participates in benzoate degradation via hydroxylation.
References
Maruyama K (February 1983). "Purification and properties of 2-pyrone-4,6-dicarboxylate hydrolase". Journal of Biochemistry. 93 (2): 557–65. PMID 6841353.
