- Source: 4-Quinolone
4-Quinolone is an organic compound derived from quinoline. It and 2-quinolone are the two most important parent (meaning simplified) quinolones. 4-Quinolone exists in equilibrium with a minor tautomer, 4-hydroxyquinoline (CAS#611-36-9). Aside from pedagogical interest, 4-quinolone is of little intrinsic value but its derivatives, the 4-quinolone antibiotics, represent a large class of important drugs.
Synthesis
The chemical synthesis of quinolones often involves ring-closing reactions. Such reactions often install a hydroxyl group (an –OH functional group) on the carbon across from the ring nitrogen (i.e., the C-4 positions). An example of such a synthesis is the Camps cyclization, which, depending on starting materials and reaction conditions, can give both 2-hydroxyquinolines (B) and 4-hydroxyquinolines (A) as shown. The hydroxyquinolines tautomerize to the quinolones.
References
Kata Kunci Pencarian:
- Kuinolon
- Bawang putih
- Asam pipemidat
- Asam nalidiksat
- Inggu
- Ofloksasin
- Fluorin
- Moksifloksasin
- 4-Quinolone
- Quinolone
- Quinolone antibiotic
- Pseudomonas quinolone signal
- 2-Quinolone
- Ciprofloxacin
- Camps quinoline synthesis
- 4-Nitroquinoline 1-oxide
- ELQ-300
- 5,7-Dichlorokynurenic acid
