- Source: 4-Trifluoromethylbenzaldehyde
4-Trifluoromethylbenzaldehyde is the organofluorine compound with the formula CF3C6H4CHO. Two other isomers are also known: 2-trifluoromethylbenzaldehyde and 3-trifluoromethylbenzaldehyde. These compounds are derivatives of benzaldehyde with trifluoromethyl substituents. The CF3 group enhances the electrophilicity of the formyl group and provides a label for analysis by fluorine-19 nuclear magnetic resonance spectroscopy.
Synthesis and reactions
It can be prepared by a Suzuki-Miyaura coupling from the 4-trifluoromethylphenylboronic acid. Complementarily, it can be produced by trifluoromethylation of 4-formylphenylboronic acid.
It readily condenses with amines to give imines. It has been used in the synthesis of pharmaceuticals, such as Lanperisone.