- Source: 5-Methyltetrahydrofolate:corrinoid/iron-sulfur protein Co-methyltransferase
5-methyltetrahydrofolate:corrinoid/iron-sulfur protein Co-methyltransferase (EC 2.1.1.258, acsE (gene)) is an enzyme with systematic name 5-methyltetrahydrofolate:corrinoid/iron-sulfur protein methyltransferase. This enzyme catalyses the following chemical reaction
[Methyl-Co(III) corrinoid Fe-S protein] + tetrahydrofolate
⇌
{\displaystyle \rightleftharpoons }
a [Co(I) corrinoid Fe-S protein] + 5-methyltetrahydrofolate
This enzyme catalyses the transfer of a carbon atom and associated hydrogen atoms from the N5 position of methyltetrahydrofolate to the 5-methoxybenzimidazolylcobamide cofactor of a corrinoid/Fe-S protein, containing a corrin ring similar to that in cobalamin. Although called a methyl transferase, the net transfer is of one carbon atom and two hydrogen atoms – the methyltetrahydrofolate contains only two hydrogen atoms more than the tetrahydrofolate. The cobalt atom is able to change oxidation state by obtaining electrons frpm the 4Fe-4S complex in the protein.
References
External links
5-methyltetrahydrofolate:corrinoid/iron-sulfur+protein+Co-methyltransferase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
Kata Kunci Pencarian:
- 5-Methyltetrahydrofolate:corrinoid/iron-sulfur protein Co-methyltransferase
- Methyltransferase
- List of EC numbers (EC 2)
- ACSE
