• Source: ABL2

Tyrosine-protein kinase ABL2 also known as Abelson-related gene (Arg) is an enzyme that in humans is encoded by the ABL2 gene.




Function


ABL2 is a cytoplasmic tyrosine kinase which is closely related to but distinct from ABL1. The similarity of the proteins includes the tyrosine kinase domains and extends amino-terminal to include the SH2 and SH3 domains. ABL2 is expressed in both normal and tumor cells. The expression of ABL2 gene is higher in KRAS mutant non-small cell lung cancer. The ABL2 gene product is expressed as two variants bearing different amino termini, both approximately 12-kb in length.




Interactions


ABL2 has been shown to interact with three proteins: Abl gene, catalase, and SORBS2. The protein Abl gene is also known as abelson murine leukemia viral oncogene homolog 1 and is a protein that is encoded by the human ABL1 gene. Catalase is a common enzyme that catalyzes the decomposition of hydrogen peroxide to water and oxygen. SORBS2 is also known as Sorbin and SH3 domain-containing protein 2 and is a protein encoded by the SORBS2 gene in humans.




References






Further reading






External links


Genes,+abl at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
Abelson+Leukemia+Virus at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
ABL2 Info with links in the Cell Migration Gateway
Human ABL2 genome location and ABL2 gene details page in the UCSC Genome Browser.

Kata Kunci Pencarian:

• Daftar gen penyandi protein pada manusia/1
• ABL2
• Tyrosine kinase
• SH2 domain
• Chromosome 1
• Catalase
• Imatinib
• List of human protein-coding genes 1
• Immunological synapse
• ABL (gene)
• Cortical granule