• Source: AKAP10

A kinase anchor protein 10, mitochondrial is an enzyme that in humans is encoded by the AKAP10 gene.




Function


The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins, which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family. The encoded protein interacts with both the type I and type II regulatory subunits of PKA; therefore, it is a dual-specific AKAP. This protein is highly enriched in mitochondria. It contains RGS (regulator of G protein signalling) domains, in addition to a PKA-RII subunit-binding domain. The mitochondrial localization and the presence of RGS domains may have important implications for the function of this protein in PKA and G protein signal transduction.




Interactions


AKAP10 has been shown to interact with PDZK1 and PRKAR1A.




References






External links


Human AKAP10 genome location and AKAP10 gene details page in the UCSC Genome Browser.




Further reading

Kata Kunci Pencarian:

• Daftar gen penyandi protein pada manusia/1
• AKAP10
• List of human protein-coding genes 1
• A-kinase-anchoring protein
• PRKAR1A
• PDZK1