- Source: Alkalihalobacillus clausii
Alkalihalobacillus clausii (synonym Bacillus clausii) is a rod-shaped, motile, and spore-forming bacterium that lives in the soil but is also a natural microbiota of the mammalian gastrointestinal tract. It is classified as probiotic microorganism that maintains a symbiotic relationship with the host organism. It is currently being studied in relation to respiratory infections and some gastrointestinal disorders. Bacillus clausii has been found to produce antimicrobial substances that are active against gram-positive bacteria including Staphylococcus aureus, Enterococcus faecium and Clostridioides difficile. It is sold as an anti-diarrhoea and under the brand name Erceflora by Sanofi.
This species has been recently transferred into the genus Alkalihalobacillus. The correct nomenclature is thus Alkalihalobacillus clausii.
The Pharmacovigilance Risk Assessment Committee (PRAC) warns about serious risks for bacteraemia and sepsis due to previous publications. PRAC stipulates marketing conditions for Bacillus clausii. Amendments to be included in the relevant sections of the Product Information (new text underlined and in bold) including
1 Bacteraemia (in immunocompromised patients)
2 In case of reduced body’s defence mechanisms and you are taking (product name)
Bacillus clausii may be found in your blood.
On Children’s Day 2023, Erceflora Kiddie probiotic brand partnered with Save the Children through the #BatangMatatag Campaign. Erceflora announced it would donate percentage of the sale to the DepEd Campaign.
Genome structure
Alkalihalobacillus clausii has a relatively small genome that contains 4.30 Mbp with 4,108 protein coding genes.
References
External links
Media related to Bacillus clausii at Wikimedia Commons
Bacillus clausii
Type strain of Bacillus clausii at BacDive - the Bacterial Diversity Metadatabase
