• Source: Alpha 2-antiplasmin

Alpha 2-antiplasmin (or α2-antiplasmin or plasmin inhibitor) is a serine protease inhibitor (serpin) responsible for inactivating plasmin. Plasmin is an important enzyme that participates in fibrinolysis and degradation of various other proteins. This protein is encoded by the SERPINF2 gene.




Role in disease


Very few cases (<20) of A2AP deficiency have been described. As plasmin degrades blood clots, impaired inhibition of plasmin leads to a bleeding tendency, which was severe in the cases reported.
In liver cirrhosis, there is decreased production of alpha 2-antiplasmin, leading to decreased inactivation of plasmin and an increase in fibrinolysis. This is associated with an increase risk of bleeding in liver disease.




Interactions


Alpha 2-antiplasmin has been shown to interact with:

Neutrophil elastase and
Plasmin.




See also


Serpin




References






Further reading






External links


The MEROPS online database for peptidases and their inhibitors: I04.023
alpha-2+Antiplasmin at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
SERPINF2+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
Human SERPINF2 genome location and SERPINF2 gene details page in the UCSC Genome Browser.

Kata Kunci Pencarian:

• Alpha 2-antiplasmin
• Alpha globulin
• Hyperfibrinolysis
• Plasmin
• Neutrophil elastase
• Antithrombin
• Trypsin 1
• PEDF
• Serpin
• Fibroblast activation protein, alpha