• Source: Alpha-actinin-1

Alpha-actinin-1 is a protein that in humans is encoded by the ACTN1 gene.




Function


Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha-actinin-1 is an F-actin cross-linking protein – a bundling protein that is thought to anchor actin to a number of intracellular structures. Alpha-actinin-1 is a non-muscle cytoskeletal isoform found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments.




Interactions


Alpha-actinin-1 has been shown to interact with:

CDK5R1,
CDK5R2,
Collagen, type XVII, alpha 1,
GIPC1,
PDLIM1,
Protein kinase N1,
SSX2IP, and
Zyxin.
PTPRT (PTPrho)




See also


Actinin




References






Further reading






External links


Actinin, alpha 1 Info with links in the Cell Migration Gateway
Human ACTN1 genome location and ACTN1 gene details page in the UCSC Genome Browser.

Kata Kunci Pencarian:

• Sitoskeleton
• Titin
• Protein Wiskott–Aldrich syndrome
• Sitoskeleton prokariotik
• Protein membran perifer
• Alpha-actinin-1
• Alpha-actinin-3
• Actinin
• Alpha-actinin-4
• Alpha-actinin-2
• Calcium/calmodulin-dependent protein kinase type II subunit alpha
• PDLIM1
• CDK5R2
• Polycystin cation channel family
• List of A1 genes, proteins or receptors