• Source: Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase

In enzymology, an alpha" target="_blank">alpha-N-acetylgalactosaminide alpha" target="_blank">alpha-2,6-sialyltransferase (EC 2.4.3.3) is an enzyme that catalyzes the chemical reaction

CMP-N-acetylneuraminate + glycano-1,3-(N-acetyl-alpha" target="_blank">alpha-D-galactosaminyl)-glycoprotein



⇌


{\displaystyle \rightleftharpoons }

CMP + glycano-(2,6-alpha" target="_blank">alpha-N-acetylneuraminyl)-(N-acetyl-D-galactosaminyl)- glycoprotein
Thus, the two substrates of this enzyme are CMP-N-acetylneuraminate and glycano-1,3-(N-acetyl-alpha" target="_blank">alpha-D-galactosaminyl)-glycoprotein, whereas its 3 products are CMP, glycano-(2,6-alpha" target="_blank">alpha-N-acetylneuraminyl)-(N-acetyl-D-galactosaminyl)-, and glycoprotein.
This enzyme belongs to the family of transferases, specifically those glycosyltransferases that do not transfer hexosyl or pentosyl groups. The systematic name of this enzyme class is CMP-N-acetylneuraminate:glycano-1,3-(N-acetyl-alpha" target="_blank">alpha-D-galactosaminyl)-glycoprotein alpha" target="_blank">alpha-2,6-N-acetylneuraminyltransferase. This enzyme participates in O-glycan biosynthesis and glycan structures - biosynthesis 1.




See also


N-acetylneuraminate, for CMP-N-acetylneuraminate and N-acetylneuraminyl




References



Sadler JE, Rearick JI, Hill RL (1979). "Purification to homogeneity and enzymatic characterization of an alpha" target="_blank">alpha-N-acetylgalactosaminide alpha" target="_blank">alpha 2 leads to 6 sialyltransferase from porcine submaxillary glands". J. Biol. Chem. 254 (13): 5934–41. PMID 447688.

Kata Kunci Pencarian:

• Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase
• Sialyltransferase
• Chromosome 17
• Α-N-Acetylneuraminyl-2,3-b-galactosyl-1,3-N-acetyl-galactosaminide 6-α-sialyltransferase
• ST6GALNAC1
• ST6GALNAC4
• ST6GALNAC6
• ST6GALNAC2
• Chromosome 9