- Source: AM-694
AM-694 (1-(5-fluoropentyl)-3-(2-iodobenzoyl)indole) is a designer drug that acts as a potent and selective agonist for the cannabinoid receptor CB1. It is used in scientific research for mapping the distribution of CB1 receptors.
Pharmacology
AM-694 is an agonist for cannabinoid receptors. It has a Ki of 0.08 nM at CB1 and 18 times selectivity over CB2 with a Ki of 1.44 nM. It is unclear what is responsible for this unusually high CB1 binding affinity, but it makes the 18F radiolabelled derivative of AM-694 useful for mapping the distribution of CB1 receptors in the body.
Metabolism
Pathways of metabolism include hydrolytic defluorination, carboxylation, and monohydroxylation of the N-alkyl chain.
See also
AM-679
AM-1235
AM-2201
AM-2232
AM-2233
FUBIMINA
JWH-018
List of AM cannabinoids
List of JWH cannabinoids
THJ-2201
References
Kata Kunci Pencarian:
- Kota Semarang
- Hochstadt am Main
- Kota Surakarta
- Iklim muson tropis
- Argentina
- ISO 3166-1
- Serotonin
- Kekristenan
- Adolf Hitler
- Siegelsbach
- AM-694
- Synthetic cannabinoids
- AM-2201
- Psilocybin mushroom
- Tetrahydrocannabinol
- Scopolamine
- Dicycloverine
- Datura
- Morning glory
- Psilocybe cyanescens
