- Source: Amino esters
Amino esters are a class of local anesthetics. They are named for their ester bond and are unlike amide local anaesthetics.
Structure
Structurally, amino esters consist of three molecular components:
a lipophilic part (ester)
an intermediate aliphatic chain
a hydrophilic part (amine)
The chemical linkage between the lipophilic part and the intermediate chain can be of the amide-type or the ester-type, and is the general basis for the current classification of local anesthetics.
Amino esters, in reference to anesthetic agents, are rapidly metabolized in the plasma by butyrylcholinesterase to para-aminobenzoic acid derivatives, then excreted in the urine. This suggests their very short half lives. Allergy is more likely to occur with ester-type agents, as opposed to amide-type.
Examples
Amino ester-type include:
Cocaine
Procaine (Novocain)
Tetracaine (Pontocaine)
Benzocaine
Chloroprocaine
References
University of Texas Med School, Pharmacology Syllabus.
Katzung. 10th edition. Chapter 26.
Kata Kunci Pencarian:
- Enzim
- Hidrolisis
- Prokain
- Azida
- Kontaminan pengolahan makanan
- Karbonilasi
- MAPK
- Reaksi Diels–Alder
- Amino esters
- Ester
- Glycine methyl ester hydrochloride
- Homologation reaction
- Amino acid
- List of local anesthetics
- Hydroxybenzotriazole
- Procaine
- Local anesthetic
- Benzocaine
