- Source: Annexin A6
Annexin A6 is a protein that in humans is encoded by the ANXA6 gene.
Function
Annexin VI belongs to a family of calcium-dependent membrane and phospholipid binding proteins. Although their functions are still not clearly defined, several members of the annexin family have been implicated in membrane-related events along exocytotic and endocytotic pathways. The annexin VI gene is approximately 60 kbp long and contains 26 exons. It encodes a protein of about 68 kDa that consists of eight 68-amino acid repeats separated by linking sequences of variable lengths. It is highly similar to human annexins I and II sequences, each of which contain four such repeats. Exon 21 of annexin VI is alternatively spliced, giving rise to two isoforms that differ by a 6-amino acid insertion at the start of the seventh repeat. Annexin VI has been implicated in mediating the endosome aggregation and vesicle fusion in secreting epithelia during exocytosis.
Interactions
ANXA6 has been shown to interact with RAS p21 protein activator 1.
References
Further reading
External links
Human ANXA6 genome location and ANXA6 gene details page in the UCSC Genome Browser.
Kata Kunci Pencarian:
- Annexin A6
- Annexin
- Annexin A5
- Annexin A1
- Annexin A2
- Dysferlin
- Selenium responsive proteins
- Synaptotagmin
- Calcium-induced calcium release
- Ryanodine receptor
