• Source: Anthranilate 3-monooxygenase

In enzymology, an 3/info/anthranilate" target="_blank">anthranilate 3-monooxygenase (EC 1.14.16.3) is an enzyme that catalyzes the chemical reaction

3/info/anthranilate" target="_blank">anthranilate + tetrahydrobiopterin + O2



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{\displaystyle \rightleftharpoons }

3-hydroxyanthranilate + dihydrobiopterin + H2O
The 3 substrates of this enzyme are 3/info/anthranilate" target="_blank">anthranilate, tetrahydrobiopterin, and O2, whereas its 3 products are 3-hydroxyanthranilate, dihydrobiopterin, and H2O.
This enzyme belongs to the family of oxidoreductases, specifically those acting on paired donors, with O2 as oxidant and incorporation or reduction of oxygen. The oxygen incorporated need not be derived from O2 with reduced pteridine as one donor, and incorporation of one ato of oxygen into the other donor. The systematic name of this enzyme class is 3/info/anthranilate" target="_blank">anthranilate,tetrahydrobiopterin:oxygen oxidoreductase (3-hydroxylating). Other names in common use include 3/info/anthranilate" target="_blank">anthranilate 3-hydroxylase, 3/info/anthranilate" target="_blank">anthranilate hydroxylase, anthranilic hydroxylase, and anthranilic acid hydroxylase. This enzyme participates in tryptophan metabolism. It employs one cofactor, iron.




References



Jequier E, Robinson DS, Lovenberg W, Sjoerdsma A (1969). "Further studies on tryptophan hydroxylase in rat brainstem and beef pineal". Biochem. Pharmacol. 18 (5): 1071–81. doi:10.1016/0006-2952(69)90111-7. PMID 5789774.
Nair PM, Vaidyanathan CS (1965). "Anthranilic acid hydroxylase from Tecoma stans". Biochim. Biophys. Acta. 110: 521–531. doi:10.1016/s0926-6593(65)80065-0.

Kata Kunci Pencarian:

• Anthranilate 3-monooxygenase
• Anthranilate 3-monooxygenase (FAD)
• Anthranilate 3-monooxygenase (deaminating)
• Anthranilate 3-hydroxylase
• Anthranilate hydroxylase
• Anthranilic acid hydroxylase
• Anthranilic hydroxylase
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