• Source: ARFGEF2

Brefeldin A-inhibited guanine nucleotide-exchange protein 2 is a protein that in humans is encoded by the ARFGEF2 gene.




Function


ADP-ribosylation factors (ARFs) play an important role in intracellular vesicular trafficking. The protein encoded by this gene is involved in the activation of ARFs by accelerating replacement of bound GDP with GTP and is involved in Golgi transport. It contains a Sec7 domain, which may be responsible for its guanine-nucleotide exchange activity and also brefeldin A inhibition.




Interactions


ARFGEF2 has been shown to interact with ARFGEF1, PRKAR1A and PRKAR2A.




References






External links


Human ARFGEF2 genome location and ARFGEF2 gene details page in the UCSC Genome Browser.




Further reading

Kata Kunci Pencarian:

• Daftar gen penyandi protein pada manusia/1
• ARFGEF2
• List of human protein-coding genes 1
• Chromosome 20
• Christopher A. Walsh
• PRKAR1A
• ARFGEF1
• PRKAR2A
• List of OMIM disorder codes