- Source: Azurocidin 1
Azurocidin also known as cationic antimicrobial protein CAP37 or heparin-binding protein (HBP) is a protein that in humans is encoded by the AZU1 gene.
Function
Azurophil granules, specialized lysosomes of the neutrophil, contain at least 10 proteins implicated in the killing of microorganisms. The protein encoded by this gene is an azurophil granule antimicrobial protein, with monocyte chemotactic and antibacterial activity. It is also an important multifunctional inflammatory mediator. The genes encoding this protein, neutrophil elastase 2, and proteinase 3 are in a cluster located at chromosome 19pter. All 3 genes are expressed coordinately and their protein products are packaged together into azurophil granules during neutrophil differentiation.
Structure
This encoded protein is a member of the PA clan of proteases but it is not a serine proteinase, because the active site serine and histidine residues are replaced, making it a pseudoenzyme.
Clinical significance
In patients with fever, high plasma levels of HBP indicates that the patient is at high risk of developing sepsis with circulatory collapse.
References
External links
Human AZU1 genome location and AZU1 gene details page in the UCSC Genome Browser.
Further reading
Kata Kunci Pencarian:
- Azurocidin 1
- HBP
- Neutrophil elastase
- Pseudoprotease
- Catalytic triad
- AZU
- Anti-neutrophil cytoplasmic antibody
- Evolution of the human oral microbiome
- PA clan of proteases
- Paucimannosylation
