- Source: Basaloid follicular hamartoma
Basaloid follicular hamartoma is a cutaneous condition characterized as distinctive benign adnexal tumor that has several described variants.: 675 It manifest as small tan or brown coloured papules in the trunk, pubic area, face, scalp, and axilla.
Basaloid follicular hamartoma is associated with a variety of disorders and is caused by mutation in the PTCH gene. The diagnosis is made based of histopathological examination.
Signs and symptoms
Basaloid follicular hamartoma manifests as multiple 1- to 2mm tan-to-brown-colored papules located on the pubic area, trunk, axilla, scalp, and face.
Causes
Basaloid follicular hamartoma can be hereditary or acquired.
Associated conditions include cystic fibrosis, systemic lupus erythematosus, myasthenia gravis, hypohidrosis, hypotrichosis, palmar pitting, and alopecia.
Basaloid follicular hamartoma is caused by a mutation in the chromosome 9q23 patch (PTCH) gene, which is also the gene responsible for nevoid basal cell carcinoma syndrome.
Diagnosis
The diagnosis of basaloid follicular hamartoma lesions requires a histopathological investigation. Histopathological features include basaloid epithelial cells in the papillary dermis form multifocal islands and branching cords, some of which are attached to the epidermis and dilated hair follicles.
Treatment
Various interventions, including photodynamic therapy, carbon dioxide laser, and surgery, have been suggested.
See also
Hamartoma
Cutaneous condition
List of cutaneous conditions
References
Further reading
Mills, Omie; Thomas, L. Brannon (2010). "Basaloid follicular hamartoma". Archives of Pathology & Laboratory Medicine. 134 (8): 1215–1219. doi:10.5858/2008-0620-RS.1. ISSN 1543-2165. PMID 20670146. Retrieved 2024-03-31.
Chikeka, Ijeuru; Chang, Li-Wei; Collins, Mary-Katherine; Pugliano, Melissa; Ho, Jonhan; House, Nancy; Kazlouskaya, Viktoryia (2022). "Basaloid Follicular Hamartoma: An Additional Criterion of Nevoid Basal Cell Carcinoma Syndrome". The American Journal of Dermatopathology. 44 (1): 66–69. doi:10.1097/DAD.0000000000001987. ISSN 0193-1091. PMID 34132667.
External links
DermNet
Pathology Outlines