• Source: Bcl-2-interacting killer

Bcl-2-interacting killer is a protein that in humans is encoded by the BIK gene.




Function


The protein encoded by this gene is known to interact with cellular and viral survival-promoting proteins, such as BCL2 and the Epstein–Barr virus in order to enhance programmed cell death. Because its activity is suppressed in the presence of survival-promoting proteins, this protein is suggested as a likely target for antiapoptotic proteins. This protein shares a critical BH3 domain with other death-promoting proteins, BAX and BAK.




Interactions


Bcl-2-interacting killer has been shown to interact with BCL2-like 1 and Bcl-2.




References






External links


Human BIK genome location and BIK gene details page in the UCSC Genome Browser.




Further reading

Kata Kunci Pencarian:

• Bcl-2-interacting killer
• Bik
• Bcl-2
• Bcl-2 homologous antagonist killer
• Howel–Evans syndrome
• Apoptosis regulator BAX
• Bcl-2-like protein 1
• BNIP3
• P53 upregulated modulator of apoptosis
• BOK (gene)