• Source: Benzhydryl compounds

    • The benzhydryl compounds are a group of organic compounds whose parent structures include diphenylmethane (which is two benzene rings connected by a single methane), with any number of attached substituents, including bridges. This group typically excludes compounds in which either benzene is fused to another ring (bicyclic, tricyclic, polycyclic) or includes a heteroatom, or where the methane connects to three or four benzenes.

    The benzhydryl radical can be abbreviated Ph2CH• or Bzh.


    Carboaromatic




    = Alcohols

    =
    Acyclic: pridinol
    Pyrolidino: diphenylprolinol
    2-Piperidine: pipradrol
    4-Piperidine: terfenadine, fexofenadine
    Benzilic ester: QNB, JB-336, JB-318, benactyzine


    = Alkenes

    =
    Tricycle: amitriptyline, melitracen, cyclobenzaprine, tianeptine, amineptine, clopenthixol, chlorprothixene, flupentixol, thiothixene, zuclopenthixol
    Tricyclic and piperidine: pimethixene, cyproheptadine
    Acyclic: gilutensin


    = Alkyl(amine)s

    =
    Acyclic: (3-phenylpropylamine), tolpropamine, tolterodine
    Piperidine: desoxypipradrol, budipine
    N-alkyl-4-piperidinol: penfluridol
    N-arylalkyl-piperidine: pimozide
    Tetrahydronaphthalene: tametraline (4-phenylaminotetralin), sertraline
    Tetrahydroisoquinoline: nomifensine, diclofensine "tetrahydronaphisoquinoline", dinapsoline (see doxanthrine and dinoxyline)
    Pyrroloisoquinoline: JNJ-7925476
    Indanamine: Lu 19-005
    Tricyclic: 9-Aminomethyl-9,10-dihydroanthracene, phenindamine (see MPTP)
    Tetracyclic: maprotiline, dihydrexidine, butaclamol, ecopipam
    Tetrahydrobenzazepine: SKF-83959, SKF-82958, SKF-81297, SKF 38393, fenoldopam, 6-Br-APB, SCH 23390
    Piperazine: amperozide
    Triazaspiro: fluspirilene


    = Alkoxy compounds

    =
    Acyclic (3 °C): diphenhydramine (c.f deramciclane), orphenadrine, p-methyldiphenhydramine
    Acyclic (4 °C): moxastine, Clemastine, embramine,
    Piperazine: GBR-12935, GBR 12909, DBL-583
    Tropine: benztropine, deptropine, etybenzatropine, difluoropine
    Piperidine: diphenylpyraline
    Phthalane: talopram, citalopram
    Octahedral: nefopam
    Benzdihydropyran: A-68930 (isochromene)


    = Amines

    =
    Piperazine: cyclizine, clocinizine, hydroxyzine, meclozine, cetirizine, dotarizine, cinnarizine
    Benzazepine: mianserin
    Tetracyclic: dizocilpine


    = Other

    =
    Aromatic alkoxy: bifemelane, phenyltoloxamine
    Keto: phenadoxone, methadone, dipipanone, etc.
    Amido: dextromoramide
    Imino: benzodiazepine, GYKI-52895
    Sulfinyl: modafinil, adrafinil
    Pituxate gem-diphenylcyclopropane


    Heteroaromatic


    These species are not strictly benzhydryl-containing but are analogous.


    = Heteroaromatic rings

    =
    Alkene: thiambutene, loratadine
    Alkylamine: A-86929, amfonelic acid


    = Benzenes linked by a non-carbon atom

    =
    Nitrogen: promethazine, imipramine, acepromazine, chlorpromazine, fluphenazine, mesoridazine, levomepromazine, perazine, periciazine, perphenazine, prochlorperazine, sulforidazine, thioridazine, trifluoperazine, triflupromazine, clozapine, thiethylperazine
    Indolic nitrogen: sertindole
    Oxygen: loxapine, asenapine, tyrima


    = Benzene and heterocycle linked through a non-carbon

    =
    Olanzapine


    References




    External links


    Benzhydryl+Compounds at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
    Bromodiphenylmethane from PubChem, a.k.a. called benzhydryl bromide
    1-Benzyl-2-bromobenzene from PubChem, not called benzhydryl bromide

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