- Source: Berberine reductase
Berberine reductase (EC 1.5.1.31) is an enzyme that catalyzes the chemical reaction
(R)-canadine + 2 NADP+
⇌
{\displaystyle \rightleftharpoons }
berberine + 2 NADPH + H+
Thus, the two substrates of this enzyme are (R)-canadine and nicotinamide adenine dinucleotide phosphate ion, whereas its 3 products are berberine, nicotinamide adenine dinucleotide phosphate, and hydrogen ion.
This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-NH group of donors with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is (R)-tetrahydroberberine:NADP+ oxidoreductase. This enzyme is also called (R)-canadine synthase.
References
Bauer W, Zenk MH (1991). "Formation of (R)-configurated tetrahydroprotoberberine alkaloids in vivo and in vitro". Tetrahedron Lett. 32 (4): 487–490. doi:10.1016/S0040-4039(00)79475-5.
Kata Kunci Pencarian:
- Berberine reductase
- List of EC numbers (EC 1)
- Aldose reductase
- Lipid-lowering agent
- Pharmacodynamics of progesterone
- Canadine
- PPAR agonist
- Intercalation (biochemistry)
- Palmatine
- Dipeptidyl peptidase-4 inhibitor
