- Source: Beta-phosphoglucomutase
In enzymology, a β-phosphoglucomutase (EC 5.4.2.6) is an enzyme that catalyzes the chemical reaction
β-D-glucose 1-phosphate
⇌
{\displaystyle \rightleftharpoons }
β-D-glucose 6-phosphate
Hence, this enzyme has one substrate, β-D-glucose 1-phosphate, and one product, β-D-glucose 6-phosphate.
This enzyme belongs to the family of isomerases, specifically the phosphotransferases (phosphomutases), which transfer phosphate groups within a molecule. The systematic name of this enzyme class is beta-D-glucose 1,6-phosphomutase. This enzyme participates in starch and sucrose metabolism.
Structural studies
20 structures have been solved for this enzyme PDB. Some of the accession codes are 1LVH, 1O03, 1O08, 1Z4N, 1Z4O, and 1ZOL. Most of these structures detail metal fluoride analogue complexes which are used to mimic different states along the reaction coordinate.
References
Ben-Zvi R, Schramm M (1961). "A phosphoglucomutase specific for beta-glucose 1-phosphate". J. Biol. Chem. 236 (8): 2186–2189. doi:10.1016/S0021-9258(18)64053-0.
Boyer PD, ed. (1972). The Enzymes. Vol. 6 (3rd ed.). pp. 407–477.
Kata Kunci Pencarian:
- Beta-phosphoglucomutase
- Phosphoglucomutase
- List of diseases (P)
- Glucose 1-phosphate
- S100B
- Haloacid dehydrogenase superfamily
- Glycogenolysis
- Alpha-D-phosphohexomutase superfamily
- Glycogenesis
- Inborn errors of carbohydrate metabolism
