Betty Lou is a feminine double name. Notable people with the name include:
Betty Lou Bailey (1929–2007), American mechanical engineer
Betty Lou Beets (1937–2000), murderer executed in Texas
BettyLou DeCroce (born 1952), American politician from New Jersey
Betty Lou Gerson (1914–1999), American actress
Betty Lou Holland (born 1926), American actress
Betty Lou Keim (1938–2010), American actress
Betty Lou Mitchell (born 1937), American politician from Maine
Betty Lou Raskin (died 2010), American chemist from Maryland
Betty Lou Varnum (1931–2021), American television personality
Betty Lou Young (1919–2010), American writer and conservationist
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