- Source: Bone morphogenetic protein 3
3/info/bone" target="_blank">Bone 3/info/morphogenetic" target="_blank">morphogenetic 3/info/protein" target="_blank">protein 3, also known as osteogenin, is a 3/info/protein" target="_blank">protein in humans that is encoded by the BMP3 gene.
The 3/info/protein" target="_blank">protein encoded by this gene is a member of the transforming growth factor beta superfamily. It, unlike other 3/info/bone" target="_blank">bone 3/info/morphogenetic" target="_blank">morphogenetic proteins (BMP's) inhibits the ability of other BMP's to induce 3/info/bone" target="_blank">bone and cartilage development. It is a disulfide-linked homodimer. It negatively regulates 3/info/bone" target="_blank">bone density. BMP3 is an antagonist to other BMP's in the differentiation of osteogenic progenitors.
It is highly expressed in fractured tissues.
Cancer
BMP3 is hypermethylated in many cases of colorectal cancer (CRC) and hence along with other hypermethylated genes, may be used as a biomarker to detect early stage CRC.
References
External links
Human BMP3 genome location and BMP3 gene details page in the UCSC Genome Browser.
Further reading
Kata Kunci Pencarian:
- Protein morfogenetik tulang 1
- BMPR1B2
- Transisi epitelial-mesenkimal
- Kanker pankreas
- Metaloprotease
- Sistem saraf
- Hipertensi paru
- Kemandulan pada wanita
- Bone morphogenetic protein 3
- Bone morphogenetic protein
- Bone morphogenetic protein 4
- Bone morphogenetic protein 2
- Bone morphogenetic protein 1
- Bone morphogenetic protein receptor
- Bone morphogenetic protein 7
- Bone morphogenetic protein 6
- Bone morphogenetic protein 8B
- Bone morphogenetic protein 15
