- Source: BQ-123
BQ-123, also known as cyclo(-D-Trp-D-Asp-Pro-D-Val-Leu-), is a cyclic pentapeptide that was first isolated from a fermentation broth of Streptomyces misakiensis in 1991. NMR studies indicate that the polypeptide backbone consists of a type II beta turn and an inverse gamma turn. The side-chains adopt different orientations depending on the solvent used. The proline carbonyl oxygen atom located at the onset of a beta turn is a sodium ion binding site. It has a high affinity for sodium ions and can coordinate up to three of them. Studies have shown that BQ123 is effective in reversing Ischemia-induced acute renal failure, and it has been suggested that this might be because BQ123 increases reabsorption of sodium ions in the proximal tubule cells.
BQ-123 is a selective ETA endothelin receptor antagonist. As such, it is used as a biochemical tool in the study of endothelin receptor function. BQ-123 works as an ET-1 antagonist by reversing already established contractions to ET-1. This indicates that BQ-123 can work as an antagonist to remove ET-1 from its receptor (ETA).
References
Kata Kunci Pencarian:
- Radon
- (436755) 2011 YG13
- (202797) 2008 QR30
- 2013 AZ155
- 2011 YW43
- 2010 VA167
- (243494) 2009 UF74
- Transporter anion organik
- Sistem Satuan Internasional
- (467777) 2009 WM24
- BQ-123
- BQ
- Endothelin receptor antagonist
- Bloc Québécois
- BQ Aquaris E4.5
- List of compounds with carbon numbers 30–39
- List of signaling peptide/protein receptor modulators
- Comparison of bq smartphones
- Radon
- SARS-CoV-2 Omicron variant
