• Source: Cartilage oligomeric matrix protein

Cartilage oligomeric matrix protein (COMP), also known as thrombospondin-5, is an extracellular matrix (ECM) protein primarily present in cartilage. In humans it is encoded by the COMP gene.




Function


The protein encoded by this gene is a noncollagenous extracellular matrix (ECM) protein. It consists of five identical glycoprotein subunits, each with EGF-like and calcium-binding (thrombospondin-like) domains. Oligomerization results from formation of a five-stranded coiled coil and disulfide bonds. Binding to other ECM proteins such as collagen appears to depend on divalent cations. Mutations can cause the osteochondrodysplasias pseudoachondroplasia (PSACH) and multiple epiphyseal dysplasia (MED).
COMP is a marker of cartilage turnover. It is present in high quantities in fibrotic scars and systemic sclerosis, and it appears to have a role in vascular wall remodeling.




References






Further reading






External links


GeneReviews/NCBI/NIH/UW entry on Pseudoachondroplasia
GeneReviews/NCBI/NIH/UW entry on Multiple Epiphyseal Dysplasia, Dominant
cartilage+matrix+protein at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

Kata Kunci Pencarian:

• Cartilage oligomeric matrix protein
• Multiple epiphyseal dysplasia
• Pseudoachondroplasia
• Tendon
• ADAMTS7
• Comp
• Protein adsorption
• Osteoarthritis
• Osteochondrodysplasia
• Proteoglycan 4