• Source: Catharanthine

Catharanthine is a terpene indole alkaloid produced by the medicinal plant Catharanthus roseus and Tabernaemontana divaricata. Catharanthine is derived from strictosidine, but the exact mechanism by which this happens is currently unknown. Catharanthine is one of the two precursors that form vinblastine, the other being vindoline.




Pharmacology


(+)-Catharanthine competitively inhibits α9α10 nAChRs with potencies higher than that at α3β4 and α4β2 nAChRs and directly blocks CaV2.2. Catharanthine alkaloids are non competitive antagonist of muscle type nAChRs and this is thought to be the case due to presence of catharanthine moiety in those compounds. In in vitro study, it increased the levels of cAMP by inhibiting cAMP phosphodiesterase in brain. It is a potent inhibitor of TRPM8, similar to BCTC. Structural analysis of catharanthine shows activity on TRPM8, TRPA1, and butyrylcholinesterase.




See also


Akuammicine
Conopharyngine
Stemmadenine
Tabersonine
Dimerization of catharanthine and vindoline




References






External links


Jadhav, A.; Liang, W.; Papageorgiou, P. C.; Shoker, A.; Kanthan, S. C.; Balsevich, J.; Levy, A. S.; Heximer, S.; Backx, P. H.; Gopalakrishnan, V. (2013). "Catharanthine dilates small mesenteric arteries and decreases heart rate and cardiac contractility by inhibition of voltage-operated calcium channels on vascular smooth muscle cells and cardiomyocytes". The Journal of Pharmacology and Experimental Therapeutics. 345 (3): 383–392. doi:10.1124/jpet.112.199661. PMID 23532933. S2CID 206501362.

Kata Kunci Pencarian:

• Tapak dara
• Alkaloid vinka
• Catharanthine
• Dimerization of catharanthine and vindoline
• Vinca
• Catharanthus roseus
• Vinca alkaloid
• Alkaloid
• Vinorelbine
• Indole alkaloid
• Chemotherapy
• Tabernaemontana divaricata