• Source: Cathepsin L2

Cathepsin L2 (EC 3.4.22.43, also known as cathepsin V or cathepsin U) is a protein encoded in humans by the CTSV gene.
The protein is a human cysteine cathepsin, a lysosomal cysteine protease with endopeptidase activity.
The protein is a member of the papain-like protease family (MEROPS family C1), a lysosomal cysteine protease with endopeptidase activity. It may play an important role in corneal physiology. This gene is expressed in colorectal and breast carcinomas but not in normal colon, mammary gland, or peritumoral tissues, suggesting a possible role for this gene in tumor processes.




Clinical significance


Cathepsin L2 may play a role in the pathogenesis of keratoconus.




References






External links


The MEROPS online database for peptidases and their inhibitors: C01.009 Archived 22 February 2021 at the Wayback Machine
Cathepsin+V at the U.S. National Library of Medicine Medical Subject Headings (MeSH)




Further reading

Kata Kunci Pencarian:

• Cathepsin L2
• Cathepsin
• Cathepsin L
• Cathepsin L1
• Cathepsin Z
• SLPI
• Chromosome 1
• Proteases in angiogenesis
• Calpain
• PRDM1